The aim of this study was to develop a herbal combination formulation of turmeric (Curcuma longa), meniran (Phyllanthus urinaria), Sambiloto (Andrographis paniculata), Ginger (Zingiber officinale), Lemongrass (Cymbopogon citratus), and Lemon (Citrus limon) in the form of micro and nanoemulsions and test its activity as an immunomodulator in vitro and in vivo. The method used in this study was the preparation of aqueous and ethanol extracts of herbal combinations from A. paniculata and P. urinaria herbs, C. longa and Z. officinale rhizomes, C. limon fruit, and C. citratus , preparation of nanoemulsion herbal extract combinations, testing in Vivo nanoemulsion activity of combined herbal extracts, and in silico activity test of chemical compound components in each plant A. paniculata and P. urinaria herbs, C. longa and Z. officinale rhizomes, C. limon fruit, and C. citratus molecularly dock. The results showed that herbal combination extracts in the form of micro and nanoemulsions had potential as immunomodulators, which showed that there was an effect of natural and adaptive immune responses such as increasing the number of white blood cells, as well as decreased expression of IL-6 cytokines and IFN-gamma cytokines between the control group. and treatment. The results of determining the mechanism of its activity by molecular docking of the main protein (MPRO) of SARS-CoV-2, with comparisons of remdesivir, favipiravir, and ritonavir showed that the chebulanin compound, albibrissinoside found in meniran plants has better antiviral activity compared to the positive control drug compound , as well as neoandrographolide in Sambiloto and hesperidin in Citrus Lemonia also have good activity.
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Development of Anti-Covid-19 Herbal Combinations in Micro And Nanoemulsion Forms and Tests of Its Activity as Immunity Response Modulator
Prof. Dr. Sri Atun, M.Si.
dr. Kartika Ratna Pertiwi, M.Biomed.Sc, Ph.D.
Problem-Based Learning Model (Pbl) with a Naturalist Intelligence Based to Improve Student's Scientific Literacy in Elementary School
Prof. Dr. Suyanta, M.Si.
Prof. Dr. Insih Wilujeng, M.Pd.
Education in Indonesia continues to improve. Improvements are aimed at aspects of learning innovation. Along with the times, elementary school students are required to have 21st century skills such as scientific literacy. This research is a development research. The focus of located development is on the Problem Based Learning learning model based on naturalist intelligence which is adopted from the Narrative aspect of Multiple Intelligence theory. The purpose of this research is as a form of learning innovation in 4th grade elementary school students. Teachers as agents of change can also use this research as a variation of innovative learning models. With this research, elementary school students who are the research subjects can improve literacy. The results showed that the Pro-Based Caturalis model produced a valid value with an average result of 84%. The research subject was conducted at 6 elementary schools in the City and Regency of Magelag involving 120 students. Student responses to the implementation of the majority model in the Good and very good categories. The Pro-Based Caturalis Learning Model can increase the scientific literacy of elementary school students with an average pretest score of 67, which is proven by the posttest score of 82, especially in the matter of changes in energy forms. This result is influenced because the steps of the learning model developed include activities outside the classroom to stimulate students to use all their senses to learn science.
PBL-HL Model Oriented to Socio- Scientific Issues on the Teaching of Ecosystem to Improve the Conceptual Knowledge and Environmental Literacy of High School Students
Silvi Puspa Widya Lubis
Prof. Dr. I Gusti Putu Suryadarma, MS.
Prof. Dr. Paidi, M.Si.
This study aims to: (1) produce a valid PBL-HL model oriented to socio-science issues to be used in high school biology learning to increase students' contextual knowledge and environmental literacy, (2) reveal the practicality of the PBL-HL model produced above, (3) reveals the effectiveness of the resulting PBL-HL Model learning model. The development model uses the ADDIE model which includes the stages of analysis, design, development, implementation and evaluation. The test subjects were class X high school students in Aceh Besar District, which is located in a coastal area. Research data to determine the feasibility of the model were analyzed using the Aiken's V formula, and to see the differences and effectiveness of the model on the dependent variable using MANOVA. The results of this study are as follows. (1) The model developed is practically based on a very high category wide trial. The combination of learning models with Acehnese maritime customs and using social science issues that exist in the surrounding environment can benefit students to gain an understanding of subject matter from local cultural values, and increase contextual knowledge and environmental literacy. (3) The developed model is significantly effective in increasing students' conceptual knowledge, and is expected to foster their literacy so that they develop an attitude of loving and caring for the environment.
Developing the Flipped Classroom Model in Learning to Introduce Accounting to Increase Critical Thinking Skills and Student Learning Responsibility
Prof. Sukirno, S.Pd., M.Si., Ph.D.
Dr. Drs. L. Hendrowibowo, M.Pd.
Learning responsibility (learning responsibility/LR) and critical thinking skills (CTS) are two skills needed in the 21st century, so important to students, including accounting students. CTS is essential for accounting field graduates to understand increasingly complex accounting problems. This reason has prompted many organizations around the world to suggest that a few accounting students develop CTS. On the other hand, the student is also required to be able to take responsibility for his own learning, so that he can become a more independent person and can support the success of his learning. However, various literatures show that CTS and LR students have not been optimally developed in college. One model of learning that is believed to be able to facilitate the development of both situations is the flipped classroom (FC). The purpose of this research is to develop a model FC in learning accounting that is valid and effective for developing CTS and LR students. The development of FC is done by research and development (R&D). The development model used is the four D model, which generally includes four phases: define, design, develop, and disseminate. This research will be carried out in two years. In the first year, research was planned until the product was tested for effectiveness, and in the second year, the product was disseminated. Test validation model will be done by expert judgment, and test effectiveness will be done by experimental method. The result of this research is directed to reach the indicator level of Case Aptitude Technology (TKT) level 3. The expected result of this research is that the model FC in accounting learning is valid and effective for increasing CTS and LR students. The model generated is equipped with Plan of Learning Semester (RPS), video material, book model, book manual implementation model, book work student and book reflection student. Among the mandatory detargeting are two accepted (accepted) international journal articles, one article each in the first year and the second year. In the first year there are additions in the form of articles that are disseminated and published in international proceedings, as well as book models, book work by students and book reflection students by ISBN and copyright certificate, in the second year.
Service Model of Behavior Support Based on School Ecological Potency for Students with Emotional and Behavior Disorders
Prof. Dr. Edi Purwanta, M.Pd.
Dr. Budi Astuti, M.Si.
Students with emotional and behavior disorders have the characteristics of severe emotional, behavior and social problems that bother students’ learning processes and outcomes. Therefore, intensive school-based behavior support services are needed. Contextual behavior support services involve support for various ecological components of the school. Therefore, it is necessary to develop a behavior support service model as a systematic and procedural framework for developing students’ positive behavior. The aim of this research is to develop a behavior support service model based on the ecological potential of schools for students with emotional and behavior disorders. This model is needed as a reference for education authorities, school, and teachers to provide accommodative services for the development of positive behavior of students with emotional and behavior disorders. This research was a Borg & Gall research and development model carried out in two years. This first year's research focuses on needs analysis, planning, and developing a hypothetical model. The data came from a literature study to understand the service model and from FGD involving 20 special teachers and class teachers from 11 inclusive primary schools in Yogyakarta to explore the needs. The results of this first year's research indicate that an ideal service model needs to pay attention to several aspects according to its stages (service planning, student behavior assessment, service implementation with a multi-tier system of support, and monitoring and evaluation of programs and student progress), and underline to the role of the overall school ecological components starts from the closest to students, various other related parties, and their supporting policy roles. Needs analysis findings include: enforcement of assessment systems and procedure to understand students' emotional and behavior disorders and possible comorbidity; define explicit school policies and service procedure; enforcement of the procedure, components, teams, and stakeholders involved; and determining a monitoring system that is procedural, collaborative, and supported by adequate facilities.
IoT-Based Laboratory Blended Model Using MQTT Protocol and Augmented Reality as a Realistic Strategy of Increasing HOTs towards Education Sector SDGs
Prof. Dr. Dadan Rosana, M.Si.
Dr. Drs. Supahar, M.Si.
Dr. Sukardiyono, M.Si.
This research has proven that the application of the Blended Laboratory Application Based on Internet of Things (BLABIOT) in the Science Practicum uses the STEM (Science, Technology, Engineering, and Mathematics) approach this year the focus is on developing Science Process Skills (SPS) and Design Carrying Out Investigation (DCOI) as part of High order Thinking Skills, for junior high school students. The application of the STEM approach in science learning can solve the problem of the emergence of difficulties for students in connecting technological elements represented by the Internet of Things, engineering elements realized in blended laboratory applications, as well as mathematical elements in data analysis and graphics produced by multisensors physical variables based on IoT-based environment. The research methodology used in the research was field experiments in the form of implementing BLABIOT in the SMP Science laboratory and Research & Development (R&D) model0spiral (Cennamo and Kalk ) in the form of developing STEM models to improve students' SPS and DCOI. The results of the assessment based on media experts obtained an average percentage of 81.52%, while the results of the assessment from material experts obtained an average percentage of 83.5%. From these results it can be concluded that the developed BLABIOT learning media is in the good category and is suitable for use. The user response of the blended laboratory application is in very good category (80.14%). The results of the MANOVA test calculations in the table above can be seen that the significance value of the intercept test is 0.000 <0.05 so it can be concluded that there is a significant influence from the application of the STEM- based BLABIOT application on SPS and the ability to design carrying out investigations for junior high school students simultaneously. The outputs produced this year are; (1) Copyright for practical guidelines for measuring environmental parameters using the internet of things in blended laboratory applications. (2) International Journal of European Modern Studies Journal Vol 4 No 5 , October 2022, (3) Accepted in AIP Conference Proceedings of ICRIEMS, (4) presented UNIMA international conference on science and technology 2022.
Analysis of Learning Objectives Flow in Chemistry Class X Kurikulum Merdeka to Achieve Scientific Literacy on Green Chemistry in Sustainable Development
Prof. Drs. Jaslin Ikhsan, M.App.Sc., Ph.D.
Prof. Dr. Indyah Sulistyo Arty, M.S.
Every curriculum change is ideally welcomed by teachers in implementing it, because it gives more autonomy to teachers in formulating the flow and direction of learning objectives. To arrange the learning objectives flow and teaching materials, the teacher must be guided by several basic documents such as learning outcomes in Kurikulum Merdeka, and content standards of SNP, while also considering the stages of student cognitive development and the level of difficulty of teaching materials, so the teacher can choose the appropriate materials contained in textbooks. However, the reality is the teacher only guides existing textbooks without first analyzing the documents that are the basis for consideration in the preparation of the learning objectives flow. As a result, there are teaching materials that are ideally learned after understanding some of the previous concepts, given at the beginning of learning. Thus cognitive abilities that can be achieved only at the first level, remembering. This is because in the material there are terms that are not well understood by students because they have not been studied before. This qualitative study was conducted using a content analysis design. Data were collected by reviewing document content 1) learning outcomes of the Kurikulum Merdeka, 2) content standards of SNP, 3) publication articles on cognitive development theory, 4) publication articles on the difficulty level of teaching materials and 5) chemistry tektbooks. The data obtained were then processed following the steps introduced by Miles & Huberman, including: data condensation, data display, and conclusion drawing/verification. Based on a study of learning outcomes in Kurikulum Merdeka documents, content standards of SNP, cognitive development theory, and the level of difficulty of teaching materials and chemistry textbooks, to achieve scientific literacy on green chemistry in sustainable development in class X chemistry of the Kurikulum Merdeka resulted in a learning objectives flows as follows: semester 1 consists of three learning objectives, namely 1) explaining the rules of scientific work, 2) understanding atomic structure and its application in nanotechnology, 3) writing chemical reactions and applying the basic laws of chemistry, and semester 2 consists of two learning objectives namely 4) explaining chemistry in daily life, and 5) applying chemical concepts in environmental management. Based on the five learning objectives, the green chemistry in sustainable development can be integrated into the 5th learning goal, in semester 2. So, it can be concluded that the preparation of the learning objective flow in the chemistry subject of class X Kurikulum Merdeka should be guided by learning outcomes in Kurikulum Merdeka, content standards of SBP, theory of student cognitive development, and level of difficulty of teaching materials, not only in existing textbooks.
Prototype of Cast-based Ergonomic Electric Folding Bike for Small-Medium Industries Product Development
Dr. Ir. Heri Wibowo, ST., MT.
Ir. Dr. Mujiyono, IPU, M.T.
Dr. Apri Nuryanto, S.Pd., S.T., M.T.
Electric bicycles are the development of bicycles that function as a means of transportation and are now changing their function to sports equipment that is currently in demand by the public. In general, electric bicycles are formed from the main components, namely the frame, handlebar, axle, saddle, wheels, brakes and an electric motor is installed from battery power. Alternative frame production technology is needed to reduce dependence on imports and so that the bicycle frame production process can be produced by small-medium industries. The electric folding bicycle model needs to be developed considering that the middle and upper market segment requires a flexible electric bicycle. The aims of this study were 1) to develop an ergonomic design of an electric folding bicycle frame, and ready for small-medium industries production, 2) to develop an effective and efficient electric folding bicycle frame production process, and 3) to make a prototype of an ergonomic electric folding bicycle at a competitive price. The stages of research by applying research and development methods are as follows: 1) The process of analyzing geometric needs; 2) folding bicycle frame design; 3) frame design simulation; 4) validation and revision of the frame design; 5) the production process of a combination of cast and welded frames; 6) folding bicycle frame testing; 7) bicycle component assembly, 8) folding bicycle function test, 9) bicycle electrical system assembly; 8) electrical function test; 9) limited trial of electric folding bicycles; 10) electric bicycle prototype production. The results show that the frame design developed for this folding electric bicycle applies 5 main components, namely the head tube, seat tube, right main frame, left main frame and hinges. The simulation results with Ansys software show that the maximum stress due to a load of 2000 N is 61 MPa, so it is still below the strength threshold for cast aluminum, which is 165 MPa. The production process for folding electric bicycle frames uses 2 methods, namely casting to make frame components and the TIG welding method to assemble frame components into complete frames. The production cost of the folding electric bicycle frame prototype per unit is IDR 1,330,000. The complete prototype of a folding electric bicycle using a 500 W battery has a production cost per unit of Rp. 10.750.000,-.
Dr. Anna Rakhmawati, S.Si.,M.Si.
Dr. Dra. Bernadetta Octavia, M.Si.
Dr. Siti Marwati, S.Si., M.Si
The use of masks during and after the COVID-19 pandemic has led to an increase in disposable mask waste. Disposable mask waste is difficult to degrade so it will endanger health and the environment. Therefore, an environmentally friendly and sustainable method with biodegradation using bacteria is needed. This research aims to develop bacteria isolated from landfills (TPS), mangroves, and beaches in Java, Indonesia for mask biodegradation. The research was conducted for two years. The first year of developing the potential of Indonesian local bacteria began with isolating bacteria from TPS, mangroves and beaches as well as studying the metagenome of the diversity of mask-degrading bacteria. The isolated bacterial were then characterized and identified. Moreover, the effect of differences media and environmental conditions was studied for optimal bacterial growth on a laboratory scale. Bacterial isolates that have the potential to be obtained by selecting the ability to degrade various types of masks. The differences of cell conditions and the environment that affect the degradation process are also determined. The degraded masks by bacteria were characterized by physical and chemical properties including functional groups with FTIR and surface observations with SEM-EDX. In year II, laboratory-scale simulations of selected bacterial isolates were carried out as a result of the first year's research. The research was initiated by determining the cellular mechanism of mask degradation by selected bacterial isolates. Testing of a consortium of different types of bacteria was carried out to determine the effectiveness of the degradation of various types of masks. Furthermore, the hazardous by-products of mask degradation including the presence of microplastics, heavy metals, and discoloration were investigated. The use of bacteria as a biodegradation agent is also expected to be able to overcome these by-products. Therefore, testing the ability of selected bacterial isolates to degrade microplastics, remove heavy metals, and reduce color. Simulations on the ability of selected bacterial isolates to degrade various types of masks were carried out on laboratory-scale substrates of soil, freshwater, brackish water, and seawater. In addition, simulations of the degradation of various types of masks were carried out by selected bacterial isolates at different times and environmental conditions such as pH, temperature, and light. The results of the first year's research carried out a bacterial metagenome study and obtained pure isolates of bacteria in mask waste from 9 locations i.e 3 TPS (Piyungan, Jatibarang, Burangkeng); 3 mangroves (Wanatirta, Tirang, Teluknaga); and 3 beaches (Parangtritis, Marina, Tanjung Pasir) located in Yogyakarta, Semarang, Tangerang and Bekasi. The results of the metagenome study show the diversity of bacteria with the dominance of Phylum Proteobacteria. The results of the selection of 302 pure bacterial isolates showed that 7 types of selected bacteria, namely Bacillus cereus (2), Pseudomonas aeruginosa, Proteus mirabilis (2), Staphylococcus sciuri, and Staphylococcus arlettae were superior in degrading various types of masks (duckbill, medical, KF94). The physiological, molecular, and ability of bacteria to degrade masks are known. Optimization of bacterial conditions and environmental factors that affect it has been carried out. The first year outcomes that have been achieved are two articles submitted in Scopus indexed international journals, one article published in Scopus indexed proceedings (AIP), one book chapter, and participation as a presenter in two international seminars. The results of the first year's research reached the Technology Readiness Level (TKT) were TKT 1 and TKT 2 while the second year would reach TKT 3.
Determination of Biomarker for Progression and Immunity Status of Patients with Type II Diabetes Mellitus as Comorbid of Covid-19
dr. Kartika Ratna Pertiwi, M.Biomed.Sc, Ph.D.
Dr. Evy Yulianti, S.Si., M.Sc.
Dr. Dra. Retno Arianingrum, M.Si.
Indonesia is ranked 5th in terms of the highest number of Diabetes Mellitus (DM) sufferers in the world. DM is the main co-morbid of cytokine storms that lead to poor Covid-19 outcomes. Advance Glycation End Products (AGEs) are the end products of protein glycation under conditions of hyperglycemia, which are suspected to play an important role in the pathogenesis of DM complications, while Extracellular Traps (ETs) are products of immune cells that play a role in the immune response against pathogens, also trigger blood clots and tissue damage. The general objective of this study was to determine the potential of AGEs and ETs as biomarkers in determining the progression and immunity of DM patients against pathogenic infections. The specific objective of this study was to determine the differences in Advance Glycation End Products (AGEs) and Extracellular Traps (ETs), as well as the relationship between the two in STZ-induced DM mice and those exposed to SA infection, during a period of 14 days of treatment. . This study was an in vivo experiment on male white rats with Wistar strain induced DM with Streptozotocin and infected with Staphylococcus aureus. Parameters examined were: plasma glucose and H2O2 levels with a spectrophotometer, CML, IL-8, MPO and CitH3 levels with ELISA. The results of this study were: 1) there was a significant difference in the mean levels of the DM progression parameters, namely H2O2 and CML between the treatment groups post STZ induction and SA infection and on the 7th and 14th day of treatment, 2) there were significant differences in the mean levels of the DM immunity parameters MPO, IL-8 and CitH3 which were significant between the treatment groups after STZ induction and SA infection and on the 7th and 14th day of treatment, as well as a strong correlation between CML with MPO and CitH3 on the 7th day, as well as a strong correlation between H2O2 and MPO on the 7th and 14th days and with CitH3 on the 3rd day. This research is a basic research with the current level of technological readiness at TKT 1 and is expected to end the study in TKT 2. The output of this research is a paper that was presented at the 9th ICRIEMS and will be published in proceedings indexed by the Scopus database (submitted). Mandatory outputs are draft articles that will be addressed to Heliyon Journal, SJR Q1 (manuscript in preparation), Sains Malaysiana, SJR Q2 (manuscript in preparation),